How do Mysimba tablets work for weight loss?

Mysimba combines two active ingredients: bupropion (an antidepressant and dopamine reuptake inhibitor that stimulates hunger-reducing POMC neurons) and naltrexone (which blocks opioid receptors preventing the brain from dampening the satiety signal). Together, they regulate appetite and reduce the rewarding pleasure associated with food cravings.

What is the dosing schedule for Mysimba?

Mysimba starts at 1 tablet in the morning for Week 1. Week 2: 1 tablet morning and 1 evening. Week 3: 2 tablets morning and 1 evening. Week 4 onward: 2 tablets morning and 2 evening (4 tablets daily maintenance dose).

Can Mysimba be taken if I am afraid of injections?

Yes, Mysimba is an oral tablet and is an ideal alternative for patients who do not wish to use injectable treatments like Mounjaro or Wegovy.

Needle-Free Oral Tablet Dual Reward Pathway Action MHRA Licensed

Mysimba: The Leading Needle-Free Prescription Weight Loss Tablet

Mysimba is an innovative oral prescription treatment combining naltrexone and bupropion. Designed specifically for adults who struggle with cravings and emotional eating, providing a proven needle-free alternative.

~8.1%

Avg Weight Loss

Oral

No Needles

Dual Action

Hypothalamus + Dopamine

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Key Prescription Facts

Active Ingredients:: Naltrexone 8mg / Bupropion 90mg
Form:: Prolonged-Release Tablets
Administration:: Oral (With Meals)
Eligibility:: BMI ≥ 30 (or ≥ 27 w/ risk)
Dispensed by:: Click Pharmacy (UK)

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How Mysimba Targets Food Cravings

Unlike GLP-1 injections which work heavily on digestive transit, Mysimba works centrally within the brain's hypothalamus (hunger control) and mesolimbic dopamine circuit (reward system):

Bupropion Action

Bupropion stimulates pro-opiomelanocortin (POMC) neurons in the hypothalamus, prompting the release of alpha-MSH and beta-endorphin which signal feelings of fullness and reduce appetite.

Naltrexone Synergistic Action

Normally, beta-endorphin triggers an autoinhibitory feedback loop that shuts down POMC activation. Naltrexone blocks this inhibitory loop, allowing bupropion to maintain sustained satiety and curb compulsive snacking.

Mysimba 4-Week Titration Schedule

To reduce the incidence of nausea or headache, tablets are escalated over four consecutive weeks:

Week 1:

1 tablet in the morning

1 Tab / Day

Week 2:

1 tablet in the morning + 1 tablet in the evening

2 Tabs / Day

Week 3:

2 tablets in the morning + 1 tablet in the evening

3 Tabs / Day

Week 4 Onward:

2 tablets in the morning + 2 tablets in the evening (Maximum Dose)

4 Tabs / Day (Full Dose)

Discreet Delivery

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