UK Weight Loss Medications Comparison Matrix
Compare all 7 licensed weight loss treatments available in the UK. Filter by administration method or explore clinical efficacy, dosing, and eligibility.
| Medication | Active Ingredient | Type / Frequency | Avg Weight Loss | NICE Eligibility | Consultation |
|---|---|---|---|---|---|
|
Mounjaro
Dual GIP
View Guide →
|
Tirzepatide |
Injection
Once Weekly (KwikPen) |
Up to 20.9% | BMI ≥ 30 (or ≥ 27 with comorbidity) | Click Pharmacy → |
|
Wegovy
GLP-1
View Guide →
|
Semaglutide |
Injection
Once Weekly (FlexTouch) |
~15.0% | BMI ≥ 30 (or ≥ 27 with comorbidity) | Click Pharmacy → |
|
Saxenda
GLP-1
View Guide →
|
Liraglutide |
Injection
Once Daily (Pre-filled Pen) |
~8.0% | BMI ≥ 30 (or ≥ 27 with comorbidity) | Click Pharmacy → |
|
Mysimba
Oral
View Guide →
|
Naltrexone / Bupropion |
Tablet
Twice Daily (at full dose) |
~8.1% | BMI ≥ 30 (or ≥ 27 with risk) | Click Pharmacy → |
|
Orlistat 120mg
Generic
View Guide →
|
Orlistat (120mg) |
Capsule
1 with fat meals (up to 3x/day) |
~5 - 10% | BMI ≥ 30 (or ≥ 28 with risk) | Click Pharmacy → |
|
Xenical 120mg
Brand
View Guide →
|
Orlistat (Roche Brand) |
Capsule
1 with fat meals (up to 3x/day) |
~5 - 10% | BMI ≥ 30 (or ≥ 28 with risk) | Click Pharmacy → |
|
Alli 60mg
OTC
View Guide →
|
Orlistat (60mg) |
Capsule
1 with main meals (up to 3x/day) |
~5% boost | BMI ≥ 28 (No doctor prescription) | Click Pharmacy → |
2026 Mounjaro & Wegovy Stock & Dose Tracker
Check verified stock status across licensed UK pharmacies for each specific pen dosage strength.
In stock at Click Pharmacy. From £149 / £129 with free online clinical review and cold-chain next-day delivery.
Widely out of stock at high-street chains, but available for express refrigerated tracked dispatch on Click Pharmacy.
All treatments reviewed by UK registered prescribers under NICE TA940 & TA875 clinical criteria.
Which Treatment Is Right For Me?
Choosing between weekly injections (Mounjaro, Wegovy), daily injections (Saxenda), or oral therapies (Mysimba, Orlistat, Alli) depends on your personal health profile, needle tolerance, lifestyle, and medical history.