The Official Mounjaro Titration Schedule
Mounjaro (tirzepatide) is administered as a once-weekly subcutaneous injection using the pre-filled multi-dose KwikPen. Because tirzepatide stimulates both GIP and GLP-1 receptors, patients must undergo gradual monthly dose escalation (titration) to allow the gastrointestinal tract to adapt and prevent severe nausea.
| Month / Stage | Dose | Primary Clinical Objective |
|---|---|---|
| Month 1 (Weeks 1–4) | 2.5 mg | Initiation dose; tolerability assessment (not therapeutic for weight loss). |
| Month 2 (Weeks 5–8) | 5.0 mg | First therapeutic dose; noticeable appetite suppression begins. |
| Month 3 (Weeks 9–12) | 7.5 mg | Intermediate escalation for patients requiring further appetite control. |
| Month 4 (Weeks 13–16) | 10.0 mg | High-efficacy therapeutic dose in SURMOUNT-1 clinical trial. |
| Month 5 (Weeks 17–20) | 12.5 mg | Advanced escalation for continued progress. |
| Month 6+ (Maintenance) | 15.0 mg | Maximum licensed maintenance dose (achieved 20.9% avg weight loss). |
Do You Have to Move Up Every 4 Weeks?
No. UK prescribers frequently keep patients on a maintenance dose (such as 5mg, 7.5mg, or 10mg) if they are consistently losing 1 to 2 lbs per week and experiencing no intolerable side effects. You should only escalate your dose in discussion with your prescriber at Click Pharmacy if weight loss has plateaued for 3–4 consecutive weeks.
How and Where to Inject Mounjaro
Mounjaro is injected subcutaneously (under the skin) once every 7 days, at any time of day, with or without meals. Recommended injection sites include:
- Abdomen: At least 2 inches away from the belly button.
- Front of Thighs: Outer or middle third of the anterior thigh.
- Upper Arms: Outer fleshy area of the tricep (usually easiest with assistance).
Tip: Rotate your injection site each week to prevent local skin irritation or fatty tissue buildup (lipodystrophy).
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Frequently Asked Questions
What happens if I miss a dose of Mounjaro? ↓
If fewer than 4 days (96 hours) have passed since your missed injection, take it as soon as you remember. If more than 4 days have passed, skip the missed dose and resume your regular injection schedule on your normal day.
Can I stay on Mounjaro 5mg long term? ↓
Yes. If 5mg continues to provide sufficient appetite suppression and steady weight reduction, UK prescribers often recommend remaining on 5mg rather than increasing cost and potential side effects.